The research progress of DNA methylation in the pathogenesis and treatment of epilepsy / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 449-452, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-497537
ABSTRACT
DNA methylation is an important epigenetic modification,functioning under the regulation of DNA methyltransferase(DNMT),interacting with other epigenetic mechanisms and participating in the regulation of gene expression and differentiation process of cells.Many DNA methylation related changes are found in epilepsy and the emerging role of DNA methylation in epileptogenesis is becoming even more obvious.Here,we discuss the research progress of DNA methylation in the pathogenesis of epilepsy,and the perspectives of epigenetic medicine as new therapeutic strategy in epilepsies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2016
Type:
Article
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