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Association between XPC Lys939Gln (A/C) gene polymorphism and the susceptibility of gastric cancer:a Meta-analysis / 国际肿瘤学杂志
Journal of International Oncology ; (12): 597-602, 2016.
Article in Chinese | WPRIM | ID: wpr-497583
ABSTRACT
Objective To explore the association between Xeroderma pigmentosum complementation C group (XPC) Lys939Gln (A/C) gene polymorphism and the susceptibility of gastric cancer.Methods By searching PubMed,Cochrane Library,Elsevier,Springer-Verlag,China National Knowledge Infrastructure,Chinese Biomedical Literature Data,VIP Database and Wanfang Database,all eligible case-control studies published up to September 2015 were selected and the quality of each article was valuated by two reviewers independently according to the inclusion and exclusion criteria.Meta-analysis was performed by using STATA 12.0 software.Odds ratio (OR) and 95% confidence interval (CI) were calculated.The text was estimated for the subgroup analysis,sensitivity analysis and publication bias test.Results A total of 7 case-control studies were included,including 2 336 cases with gastric cancer and 3 502 controls.The Meta-analysis showed that compared with the allele A,the allele C increased the risk of gastric cancer (OR =1.09,95% CI1.01-1.18,Z =2.12,P =0.034);compared to the genotype AA,the homozygous model (CC) and dominant model (CC + AC) also increased the risk of gastric cancer (CC vs.AAOR =1.19,95% CI1.00-1.42,Z =2.00,P=0.046;CC+ACvs.AAOR=1.12,95%CI1.00-1.25,Z=2.03,P=0.042).The Meta-analysis showed the statistical significance between XPC Lys939Gln (A/C) gene polymorphism and the gastric cancer risk in subgroup of Asian people (C vs.AOR =1.10,95% CI1.01-1.20,Z =2.28,P =0.023;CC vs.AAOR=l.21,95%CI1.01-1.46,Z=2.02,P=0.043;CC +AC vs.AAOR =1.13,95% CI1.01-1.27,Z =2.11,P =0.035) and the source of community in the control group (C vs.AOR =1.11,95% CI1.01-1.21,Z=2.25,P =0.024;CC vs.AAOR =1.23,95% CI1.02-1.50,Z =2.12,P =0.034).Conclusion XPC Lys939G1n (A/C) gene polymorphism may be associated with the susceptibility of gastric cancer,and genotype CC,CC + AC and allele C can increase the risk of gastric cancer.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Observational study / Prognostic study / Risk factors / Systematic reviews Language: Chinese Journal: Journal of International Oncology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Observational study / Prognostic study / Risk factors / Systematic reviews Language: Chinese Journal: Journal of International Oncology Year: 2016 Type: Article