The design of non-viral nanometer vectors for delivery of small interfering RNA / 国际药学研究杂志

ABSTRACT

RNA interference(RNAi)is a method that allows double-stranded RNA(dsRNA)to induce the target gene mRNA to degrade in the body and lead to different levels of gene silencing. Small interfering RNA(siRNA)is the effector molecules of RNAi, and needs the delivery vehicle into the cells to play a therapeutic role. Nanoscale carrier can adjust the rate of drug release ,increase permeability of biofilm,change distribution in the body,and improve bioavailability. In this manuscript,materials,structure and bio?logical characteristics of existing non-viral nanometer vectors delivery for siRNA are summarized.