Models for evaluating drug transport across blood-brain barrier:research advances / 国际药学研究杂志

ABSTRACT

Objective To introduce the structure of blood-brain barrier(BBB)and drug evaluation models,and provide ba?sic theory and experimental techniques for the evaluation of novel central nervous system(CNS)drugs. Methods The literature in re?cent 10 years on the BBB definition,structural characteristics and drug screening BBB models in vivo and in vitro were reviewed. Re?sults The composition and structural characteristics of the BBB were described,and the advantages and disadvantages of each one of these models were evaluated. Conclusion So far,there is nogold standardmodel for estimating the permeability of a compound on BBB,the optimized cell models should be combined with the BBB permeability models in vivo to predict the extent of BBB permeabili?ty of a compound.