Study on senescence and proliferation of NKT like cells in HIV infected patients after antiviral therapy / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 1354-1356, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-498669
ABSTRACT
Objective:
To better understand the changes of the NKT like cells after HIV infection and HAART treatment.Methods:
Peripheral blood from HIV-infected individuals, HAART-treatment AIDS patients and healthy controls were collected, the expression of CD57 and the proliferation ability of NKT like cells before and after HAART were analyzed by flow cytometry.Results:
We found that the percentage of NKT like cells before HAART was significantly lower than the healthy controls ( P<0.01 ) , and recovered after HAART treatment ( P<0.05 );the aging of NKT like cells was significantly higher before HAART compared with health individuals (P<0.01),and recovered after HAART treatment(P<0.05)the proliferation was significantly lower in vitro before HAART compared with healthy controls,and partial recovered after HAART.Conclusion:
After HAART treatment,the number of NKT like cells,CD57 expression and the proliferation ability of HIV infected patients were restored.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2016
Type:
Article
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