KSHV RTA upregulates expression of survivin through interacting with GC/Sp1 and p53 cis-acting elements / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 1666-1669, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-498730
ABSTRACT
AIM:
To identify the potential elements within the survivin promoter indispensable for the upregu-lation of survivin by Kaposi’ s sarcoma-associated herpesvirus encoded replication and transcription activator ( KSHV RTA).METHODS:
A series of truncated survivin promoter luciferase constructs were generated.Reporter assay and chromatin immunoprecipitation were performed to detect the interaction between RTA and the important cis-acting elements.RESULTS:
Deletion of the GC/Sp1 and p53 binding sites within the survivin promoter almost completely shut down the survivin promoter activity and the p53 cis-acting element synergistically contributes to survivin promoter activation by RTA.CONCLUSION:
KSHV RTA interacts with the GC/Sp1 and p53 cis-acting elements and regulates the expression of cellu-lar survivin by specifically increasing the activity of survivin promoter.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
2016
Type:
Article
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