Structural features and function of clusterin and its role in progression of hepatocellular carcinoma / 临床肝胆病杂志

ABSTRACT

Hepatocellular carcinoma (HCC)is one of the most common malignant tumors in China,with a very complex mechanism of de-velopment and progression.Clusterin (CLU)has been confirmed to play an important role in the development and progression of HCC.This paper reviews the molecular structure and biological function of CLU and its value for early diagnosis of HCC and analyzes its association with multi -drug resistance in chemotherapy and the prospect of targeted therapy.CLU holds promise as a new molecular marker of HCC and the therapeutic target.