Recent advances in pathogenesis and management of pruritus in cholestatic liver disease / 临床肝胆病杂志
Journal of Clinical Hepatology
;
(12): 1208-1211, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-499054
ABSTRACT
Pruritus is one of the common clinical manifestations of cholestatic liver diseases such as primary biliary cirrhosis,primary scle-rosing cholangitis,and intrahepatic cholestasis of pregnancy.Potential incentives of itching include bile salts,histamine,progesterone me-tabolites,endogenous opioid substances,and lysophosphatidic acid,according to previous studies.However,the exact pathogenesis of chol-estatic pruritus remains unclear,and the current treatment can only alleviate the symptoms in some of the patients.Novel methods for treating pruritus have been proposed and/or are being studied.The recent experimental and clinical studies on the pathogenesis and treatment of pru-ritus in cholestatic hepatitis are reviewed,in order to improve the understanding and management of cholestatic pruritus.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
Journal of Clinical Hepatology
Year:
2014
Type:
Article
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