The regulation of TLR3 on NF-κB signaling pathway and its significance in the pathogenesis of tumor / 实用肿瘤学杂志

ABSTRACT

NF-κBs is a member of Rel protein family of transcription factors ,which is expressed in all cells and is involved in important physiological and pathological regulatory mechanisms ,including the regulation of TLR3 on NF-κB signaling pathway ,which has been attracted widespread attention .This paper reviews the mo-lecular mechanisms of the regulation .We summarizes the role of host immune responses in tumor development , which is mediated by the related signal molecules .It reveals that some key proteins in the regulation have a great significance to the treatment of diseases ,as used as the therapeutic targets ,and is conducive to the understanding of function and diversity in tumor tissue .