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New progress of the research on the DNA methyltransferases in the pathogenesis of carcinoma / 实用肿瘤学杂志
Practical Oncology Journal ; (6): 75-80, 2014.
Article in Zh | WPRIM | ID: wpr-499337
Responsible library: WPRO
ABSTRACT
DNA methylation is the main profile of epigenetics .DNA methyltransferases ( DNMTs) is the main regulatory enzyme during DNA methylation .The activation of DNMTs ,the hypermethylation and low expres-sion of some tumor suppressor genes are involved in the carcinogenesis and development of various human canc -ers,which is a biomarker of poor prognosis .Both of the polymorphism of DNA methyltransferases ( DNMT3b) and tobacco smoking are risk factors of tumorgenesis .The targeted therapy of DNMTs is very popular due to its low cy-totoxity.This review will focus on new progress of the research on DNMTs in pathogenesis of carcinoma .
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Full text: 1 Index: WPRIM Type of study: Etiology_studies / Risk_factors_studies Language: Zh Journal: Practical oncology journal Year: 2014 Type: Article
Full text: 1 Index: WPRIM Type of study: Etiology_studies / Risk_factors_studies Language: Zh Journal: Practical oncology journal Year: 2014 Type: Article