New progress of the research on the DNA methyltransferases in the pathogenesis of carcinoma / 实用肿瘤学杂志
Practical Oncology Journal
; (6): 75-80, 2014.
Article
in Zh
| WPRIM
| ID: wpr-499337
Responsible library:
WPRO
ABSTRACT
DNA methylation is the main profile of epigenetics .DNA methyltransferases ( DNMTs) is the main regulatory enzyme during DNA methylation .The activation of DNMTs ,the hypermethylation and low expres-sion of some tumor suppressor genes are involved in the carcinogenesis and development of various human canc -ers,which is a biomarker of poor prognosis .Both of the polymorphism of DNA methyltransferases ( DNMT3b) and tobacco smoking are risk factors of tumorgenesis .The targeted therapy of DNMTs is very popular due to its low cy-totoxity.This review will focus on new progress of the research on DNMTs in pathogenesis of carcinoma .
Full text:
1
Index:
WPRIM
Type of study:
Etiology_studies
/
Risk_factors_studies
Language:
Zh
Journal:
Practical oncology journal
Year:
2014
Type:
Article