New progress of the research on the DNA methyltransferases in the pathogenesis of carcinoma / 实用肿瘤学杂志
Practical Oncology Journal
;
(6): 75-80, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-499337
ABSTRACT
DNA methylation is the main profile of epigenetics .DNA methyltransferases ( DNMTs) is the main regulatory enzyme during DNA methylation .The activation of DNMTs ,the hypermethylation and low expres-sion of some tumor suppressor genes are involved in the carcinogenesis and development of various human canc -ers,which is a biomarker of poor prognosis .Both of the polymorphism of DNA methyltransferases ( DNMT3b) and tobacco smoking are risk factors of tumorgenesis .The targeted therapy of DNMTs is very popular due to its low cy-totoxity.This review will focus on new progress of the research on DNMTs in pathogenesis of carcinoma .
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Prognostic study
Language:
Chinese
Journal:
Practical Oncology Journal
Year:
2014
Type:
Article
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