The advance of Nampt in gliomas / 实用肿瘤学杂志
Practical Oncology Journal
; (6): 89-92, 2014.
Article
in Zh
| WPRIM
| ID: wpr-499368
Responsible library:
WPRO
ABSTRACT
Nampt is a rate -limiting enzyme in the mammalian salvaging pathway for the synthesis of NAD that is involved in cell metabolism and proliferation .In recent years,growing research has elucidated that Nampt is correlated to various malignant tumors .It has a complex functions including regulation of energy metabo-lism and genome instability,promotion of proliferation and angiogenesis ,tumor-promoting inflammation and a-voidance of immune destruction .Recent reports indicate that Nampt is highly expressed in gliomas ,and it is close-ly related to the proliferation ,migration,invasion and prognosis of gliomas ,which will provide a new target for the glioma research and therapy .
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Index:
WPRIM
Language:
Zh
Journal:
Practical Oncology Journal
Year:
2014
Type:
Article