The research and clinical application of gastr ic carcinoma with infiltration distance / 实用肿瘤学杂志

ABSTRACT

Objective To explore the intraoperative process and determine that the stomach resection margin is accurate so as to ensure the quality of operation and improve the patients′survival rate .Method Nor-mally,tissue samples were continuously collected from two sides of visualized tumor edge as center .Specifically, the tissue samples were collected from upper side when tumor located at gastric antrum ,collected from lower side when tumor located at gastric cardia ,and collected from distant side when tumor located at gastric body .All sam-ples were processed with paraffin embedding ,staining,and were judged by the distance of tumor cell infiltration . Results The mucosa infiltration distance was more than 5 cm in 5 cases,more than 3 cm but less than 5 cm in 5 cases,and less than 3 cm in 118 cases.A total of 218 cases had less 0 cm mucosa infiltration distance ,which was visualized distance less than the microscopic .The serosa infiltration distance was more than 5 cm in 6cases,more than 3 cm but less than 5cm in 19 cases,and more or equal than 0 cm in 251 cases.A total of 95 cases had less 0 cm infiltration distance .The results of the single factor analysis showed that whether the general observed infil -tration distance of the mucosal membrane was greater than what observed under the microscope ,is associated with gender,age, maximum diameter,thickness of the tumor,external quality,and TNM stage.It significantly demon-strated the relationship of microscopic mucous membrane infiltration distance with sex , vertical diameter , thick-ness,stroma mass,and TNM stage.Stroma membrane infiltration distance significantly correlated with vertical di-ameter,the largest diameter,thickness,gross type,histological type,stroma mass,and TNM stage.Conclusion The infiltration of distance was less than 5 cm among ninety nine percent of patients with gastric cancer .There-fore,enlarged resection of 5 cm from visualized margin of tumor is necessary for operative treatment .There are as-sociations between tumor infiltration distance and vertical diameter ,thickness,stroma mass,manner of infiltration, and TNM stage .