The research on CDK4 andβ-Catenin expression and clinic significance in glioma / 实用肿瘤学杂志
Practical Oncology Journal
; (6): 404-408, 2015.
Article
in Zh
| WPRIM
| ID: wpr-499375
Responsible library:
WPRO
ABSTRACT
Objective To study the expression of CDK4 andβ-Catenin and their relevance in glioma. Methods We used immunohistochemistry to detect the expression of CDK4 andβ-Catenin in forty-five glio-ma tissues and eight normal tissues.According to the classification standard of WHO in 2000 classify and grade the tissues.Results There were significant differences of CDK4 andβ-Catenin expressions between normal tis-sues and glioma tissues(P<0.01).The expression of CDK4 and β-Catenin had positive correlation with the pathological grades of glioma and histological type and increased(P <0.05).Furthermore,the expression of CDK4 was positively correlated with the expression ofβ-Catenin in glioma(r=0.52,P<0.01).Conclusion The increased expression of CDK4 andβ-Catenin may have correlation with malignant change of glioma and oc-curance of glioblastoma,and their combination is expected to become an important indicator in assessing malignant glioma.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Practical Oncology Journal
Year:
2015
Type:
Article