The advances of the HSP90 inhibitor NVP-AUY922:applied alone or in combination with anti-tumor treatment / 实用肿瘤学杂志
Practical Oncology Journal
; (6): 284-288, 2015.
Article
in Zh
| WPRIM
| ID: wpr-499376
Responsible library:
WPRO
ABSTRACT
Heat shock protein 90(Hsp90)is a highly conserved protein which have been proved to play an important role in the development and progression of malignant transformation .As one of small molecule inhibi-tors that has been detected to have potent antitumor activity in a wide range of malignancies ,NVP-AUY922 is a pyrazole scaffold drug with many advantages such as low toxicity and stable structure .As a result of this,NVP-AUY922 is extensively considered as a new promising kind of anti -tumor drug .This review intends to update the reader on advances made over the past four years in the clinical development of NVP -AUY922 in advanced cancers.
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WPRIM
Language:
Zh
Journal:
Practical Oncology Journal
Year:
2015
Type:
Article