CLINICAL ANALYSIS OF 34 CASES OF LOW -DOSE SILDENAFIL TREATMENT OF IN-TERSTITIAL CYSTITIS / 现代医院

ABSTRACT

Objective To investigate the treatment effect of daily low dose of sildenafil treating interstitial cystitis .Methods 68 patients with interstitial cystitis in our hospital from June , 2012 to December, 2013 were divided into observation group and con-trol group by digital randomized method, 34 cases in each group.Observation group adopted daily dose of sildenafil 0.25 g treatment every day, and control group adopted the same dose of starch placebo every day.Two groups were treated for 3 months.Curative effect, micturition number a day before and after the treatment, the maximum bladder capacity, interstitial bladder inflammation shape index and problem index score ( ICSI, ICPI) , pelvic pain and urinary frequency score ( PUF) and quality of life scores ( QOL) of two groups were compared.Results The rate of significant curative effect and total effective rate of observation group were significantly higher than that of the control group, and the difference was statistically significant (p0.05).Maximum bladder capacity and QOL scores of observation group after treatment were (265.44 ±43.85) ml and (44.15 ±4.69) respectively, which were higher than the (92.45 ±25.71) ml and (22.14 ±2.97) of the control group after treat-ment and (94.12 ±23.95)ml and (22.38 ±3.18) of observation group before treatment;Urine per day, ICSI, ICPI and PUF of ob-servation group after treatment is lower than that of the observation groups after treatment and that of the control group before treat-ment, and the difference had statistically significant (p<0.05).Conclusion Daily low dose of sildenafil for treating women with in-terstitial cystitis is worthy of clinical use for it can effectively relieve clinical symptoms and improve patient's life quality.