Phylogeny and drug resistance of HIV PR gene among HIV patients receiving RT inhibitors in Iran
Asian Pacific Journal of Tropical Biomedicine
; (12): 451-454, 2016.
Article
in Zh
| WPRIM
| ID: wpr-499660
Responsible library:
WPRO
ABSTRACT
Objective: To survey the level and patterns of reverse transcriptase-based drug resistance and subtype distribution among antiretroviral-treated HIV-infected patients receiving only reverse transcriptase inhibitors in Iran. Methods: A total of 25 samples of antiretroviral therapy experienced patients with no history of using protease inhibitors were collected. After RNA extraction, reverse transcriptase-nested PCR was performed. The final products were sequenced and then analysed for drug-resistant mutations and subtypes. Results: No drug resistant mutations were observed among the 25 subjects. The results showed the following subtypes among patients:CRF 35_AD (88%), CRF 28_BF (8%), and CRF 29_BF (4%). Conclusions: A significant increase in drug resistance has been noted in recently-infected patients worldwide. Subtype distributions are needed to perform properly-designed surveillance studies to continuously monitor rates and patterns of transmitted drug resistance and subtypes to help guide therapeutic approaches and limit transmission of these variants.
Full text:
1
Index:
WPRIM
Type of study:
Qualitative_research
Language:
Zh
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2016
Type:
Article