Platelet-rich plasma combined with closed reduction and hollow screw internal fixation for femoral neck fracture / 局解手术学杂志

ABSTRACT

Objective To explore the clinical effect of autologous platelet-rich plasma ( PRP) combined with closed reduction and hol-low screw internal fixation for femoral neck fracture .Methods Totally 200 cases of femoral neck fracture were collected from May 2010 to August 2014 in our hospital .Randomly divided them into two groups , namely the PRP group and the control group , with 100 patients in each group.The PRP group were given autologous platelet-rich plasma ( PRP) combined with closed reduction and hollow screw internal fixation , while the control group were given closed reduction and hollow screw internal fixation merely .The length of stay , time of fracture healing , wound healing state , postoperative complications rate , Harris score and functional recovery of the two group were recorded and evaluated .Re-sults The average hospitalization time and fracture healing time in the PRP group were shorter than the control group .The A-grade recovery rate of the PRP group was higher than the control group , and the postoperative femoral head necrosis and nonunion rate of the PRP group were lower than that in the control group (P<0.05).The Harris score of PRP group were 87.35 and 90.82 respectively, and the excellent rate of hip function 6 months and 12 months after operation were 86%and 90%respectively .They were both higher than the control group with statistical significance (P<0.05).Conclusion PRP combined with closed reduction and hollow screw internal fixation can significant -ly shorten the healing time , reduce postoperative complications , improve hip function and postoperative quality of life in treating femoral neck fracture, and it is of high safety and efficacy.