Studies on the Killing Effect of γ Ray Irradiated Peripheral Blood Mononuclear Cells Combined with ApoG2 on Human Prostate Cancer PC-3 Cells / 中国医学物理学杂志
Chinese Journal of Medical Physics
;
(6): 1676-1680, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-500243
ABSTRACT
Objective:
To observe the killing effect of irradiated peripheral blood mononuclear cells (PBMCs) at low dose combined with apogossypolone (ApoG2) on cultured human prostate cancer PC-3 cells.Methods:
Human PBMCs were irradated by gamma ray at 1 gray,the irradiation dose rate was 17 Gy/min.The experiment were divided into PC-3 tumor cell control group,PC-3 cells with irradiated and non-irradiated PBMCs co-culture groups,ApoG2 treatment group,irradiated PBMCs and ApoG2 co-treatment group.Acridine orange/ethidium bromide (AO/EB) staining and MTT method were used to observe the killing effect of PBMCs and/or ApoG2.Results:
The killing activity of irradiated PBMCs group and ApoG2 treatment group were obviously increased and were higlaer than that of non-irradiated group (P<0.05).The killing activity of combined group were much higher than that of irradiated group and ApoG2 treatment group (P <0.01 ).Conclusion:
Irradiated PBMCs at low dose combined with ApoG2 can enhances the anti-tumor effects markedly.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Medical Physics
Year:
2010
Type:
Article
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