Restrospective Analysis of Linezolid and Teicoplanin in the Treatment of Elderly Patients with Severe MRSA Infection / 中国药房
China Pharmacy
;
(12): 4140-4142, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-500682
ABSTRACT
OBJECTIVE:
To investigate therapeutic efficacy and safety of linezolid and teicoplanin in the elderly patients with severe MRSA infection.METHODS:
97 elderly patients with severe MRSA infection were collected and divided into linezolid group (42 patients) and teicoplanin group (55 patients). Linezolid group was given linezolid 600 mg intravenously,bid;teico-planin group was given teicoplanin 400 mg intravenously,qd,double dose for the first day. Treatment course lasted for 7-21 d. Clin-ical effective rate,bacterium clearance rate and ADR were compared between 2 groups after treatment.RESULTS:
The bacterium clearance rate of teicoplanin group was 52.6%,and that of linezolid group was 73.5%;the linezolid group was significantly higher than the teicoplanin group,with statistical significance(χ2=12.57,P=0.034). Clinical effective rate was 78.6% in linezolid group and 58.2% in teicoplanin group;the linezolid group was significantly higher than the teicoplanin group,with statistical significance (χ2=9.56,P=0.018). After 14 days of treatment,APACHEⅡ score of teicoplanin group and linezolid group were (14.56±3.04) and(10.29±4.84),respectively;the teicoplanin group was lower than the linezolid group,with statistical significance(t=10.97, P=0.014). The incidence of ADR was 11.9% in linezolid group and 20.0% in teicoplanin group,with statistical significance(χ2=1.13,P=0.287).CONCLUSIONS:
Linezolid has superior curative effect to teicoplanin in the treatment of severe MRSA infection in elderly patients with good safety.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2015
Type:
Article
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