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Clinical Observation of Amlodipine Besylate Combined with Valsartan in the Treatment of Hypertension / 中国药房
China Pharmacy ; (12): 4124-4126, 2015.
Article in Chinese | WPRIM | ID: wpr-500693
ABSTRACT

OBJECTIVE:

To observe therapeutic efficacy and safety of amlodipine besylate combined with valsartan in the treatment of hypertension.

METHODS:

158 patients with hypertension were randomly divided into control group (n=78) and treatment group (n=80). Control group was treated with amlodipine besylate,2.5 mg/time,3 times/d;treatment group was addi-tionally treated with valsartan,80 mg/time,once a day. A treatment course lasted for 4 weeks,and both received 5 courses. Clini-cal efficacy,blood pressure,plasma concentrations of ET-1,NT-proBNP and Ang Ⅱ were compared between 2 groups. RE-SULTSThe compliance rates of treatment group after 4,8,12,16,20 weeks were higher than that of the control group(P0.05).

CONCLUSIONS:

Amlodipine besylate combined with valsartan can effectively control the blood pres-sure in patients with hypertension,which may be related to the inhibition of ET-1,NT-proBNP and AngⅡ.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2015 Type: Article