Uncertainty Evaluation for Content Determination of Lamivudine Tablets by HPLC / 中国药房
China Pharmacy
;
(12): 2968-2970, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-500794
ABSTRACT
OBJECTIVE:
To establish a method for the uncertainty evaluation of determining content of Lamivudine tablets by HPLC.METHODS:
HPLC was established to determine the mathematical model of Lamivudine tablets contents,analyze the uncer-tainty sources in detail and evaluate each uncertainty components and combined uncertainty to obtain the expanded uncertainty. RE-SULTSUncertainty of Lamivudine tablets contents determined by HPLC was mainly from reference purity,weighing standard and glassware tolerance. Standard uncertainty was 0.21% and expanded uncertainty was 0.42%. The range of content determination was (99.76 ± 0.42)%,k=2.CONCLUSIONS:
The method is suitable for uncertainty evaluation of Lamivudine tablets by HPLC,and provides reference for the quality control in laboratory and objective evaluation of Lamivudine tablets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2015
Type:
Article
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