Clinical Observation of Vitamin B12 Combined with Mouse Nerve Growth Factor in the Treatment of Neuro-genic Tinnitus / 中国药房
China Pharmacy
;
(12): 4657-4659, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-500853
ABSTRACT
OBJECTIVE:
To observe the efficacy and safety of vitamin B12 combined with mouse nerve growth factor in the treatment of neurogenic tinnitus.METHODS:
270 patients with neurogenic tinnitus were randomly divided into control group 1, control group 2 and observation group. Control group 1 was treated with Vitamin B12 injection 25 μg by intramuscular injection, once a day;control group 2 was treated with mouse nerve growth factor 18 μg adding into 2 ml water for injection for dissolution, once a day;observation group was treated with Vitamin B12 injection 25 μg(the usage was the same as control group 1)+mouse nerve growth factor 18 μg(the usage was the same as control group 2). 6 d was a treatment course,and it lasted 2 courses. Clinical efficacy,and sleep SPIEGEL score and incidence of adverse reactions before and after treatment in 3 groups were observed. RE-SULTSTotal effective rate in observation group was significantly higher than control group 1 and control group 2,the difference was statistically significant (P0.05). After treatment,sleep SPIEGEL score in 3 groups was significantly higher than before,and observation group was high-er than control group 1 and control group 2,the difference was statistically significant(P0.05). There were no obvious adverse reactions during treatment.CONCLUSIONS:
Vitamin B12 combined with mouse nerve growth factor has better efficacy than only vitamin B12 or mouse nerve growth factor in the treatment of neurogenic tinnitus,with good safety.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2015
Type:
Article
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