Observation on the Effect of Cefotaxime with Different Doses in Periopration Period on the Prevention of Postoperative Infection of Lung Cancer Resection / 中国药房
China Pharmacy
;
(12): 4655-4657, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-500866
ABSTRACT
OBJECTIVE:
To observe the effecacy and safety of using cefotaxime using different doses in perioprative period on the prevention of postoperative infection of lung cancer resection.METHODS:
61 patients with non-small cell lung cancer who re-ceived lung cancer resection were retrospectively analyzed divided into cefotaxime 2 g group(26 cases) and cefotaxime 4 g group (35 cases)according to dosage. Cefotaxime 2 g group was treated with Cefotaxime for injetion 2 g 30 min before operation,add-ing into 0.9% sodium chloride injection 100 ml,by intravenous infusion,if the operation time was more than 3 h,cefotaxime 2 g was intravenously infused during operation and cefotaxime 2 g was intravenously infused after operation,interval of 12 h was re-quired for preoperative and postoperative medication time and the total medication time was no more than 48 h. Cefotaxime 4 g group was treated with Cefotaxime for injection 4 g(the usage was the same as cefotaxime 2 g group). Leukocyte,hemoglobin,al-bumin,infection rate and incidence of adverse reactions in 2 groups before and after operation were observed.RESULTS:
There was no significant difference in the infection rates between 2 groups(P>0.05). Leukocyte,hemoglobin and albumin in 2 groups were significantly lower than before,the differences were statistically significant(P0.05). There were no obvious adverse reactions during treatment.CONCLUSIONS:
Small dose of ce-fotaxime has good prevention effect on the postoperative infection of non-small cell lung cancer,with good safety,which meets the principles of rational use of antibiotics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2015
Type:
Article
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