Optimization of Freeze-drying Technology of Albendazole Nanosuspension / 中国药房
China Pharmacy
; (12): 3575-3577, 2015.
Article
in Zh
| WPRIM
| ID: wpr-501055
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:To optimize freeze-drying technology of albendazole nanosuspension so as to prepare albendazole nanometer powder. METHODS:By adopting freeze-drying method,with particle size and Zeta potential as the indexes,single fac-tor test and verification were made on pre-freezing temperature and the type,ratio and mass fraction of cryoprotectants,and then the albendazole nanosuspension prepared by liquid phase precipitation method was made into albendazole nanometer powder. RE-SULTS:When the pre-freezing temperature was-20℃and the cryoprotectant was 4%glucose-mannitol(3∶7),the average parti-cle size of the prepared nanometer powder was (208.03 ± 2.13) nm,and average Zeta potential was (-15.53 ± 0.18) mV. CON-CLUSIONS:Albendazole nanometer powder with better particle size and potential can be prepared by freeze-drying technology.
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WPRIM
Language:
Zh
Journal:
China Pharmacy
Year:
2015
Type:
Article