Transdermal Behavior in vitro of Total Flavonoids and Its Monomer Component in Guyu Liniment / 中国药房
China Pharmacy
;
(12): 4345-4347, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-501117
ABSTRACT
OBJECTIVE:
To investigate transdermal behavior in vitro of total flavonoids and its monomer components in Guyu liniment.METHODS:
Vertical Franz diffusion cell was adopted to perform a test on excised mouse skin as transdermal barrier. UV spectrophotometry was used to determine the content of total flavonoids,and HPLC to determine the content of monomer flavo-noid hydroxysafflor yellow A(HSYA)to observe transdermal absorption in vitro within 12 hours.RESULTS:
The accumulative per-meation quantity Q of the total flavonoids and HSYA in Guyu liniment increased with time(t),demonstrating a significant correla-tion with t1/2,and transdermal absorption was in conformity with Higuchi equation (r=0.995 6,0.999 5);permeate flux of total flavonoids and HSYA were 126.24,47.516μg/(cm2·h).CONCLUSIONS:
The transdermal behavior of total flavonoids in Guyu lin-iment is similar to that of HSYA. Both belong to matrix diffusion-type transdermal drug delivery system,with the characteristic of long-term sustained release.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2015
Type:
Article
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