Efficacy Observation of Citalopram in the Treatment of Post-stroke Depression / 中国药房

ABSTRACT

OBJECTIVE:To observe therapeutic efficacy of citalopram in the treatment of post-stroke depression. METHODS:126 post-stroke depression patient were selected and randomly divided into observation group and control group with 63 cases in each group. Control group was given routine treatment of nervous system drugs;observation group was given citalopram,20 mg, qd,after breakfast,on the basis of control group.They were given relevant medicine for consecutive 2 months. The mental status, the levels of plasma substance P (SP),plasma adrenocorticotropic hormone releasing hormone (CRH) plasma neuropeptide Y (NPY),rehabilitation compliance were observed in 2 groups before and after treatment. RESULTS:After treatment,HAMD and NIHSS score of observation group were decreased obviously,and lower than control group, with statistical significance (P<0.05);MMSE score of observation group increased significantly,and higher than control group,with statistical significance(P<0.05). After treatment,SP and CRH levels of observation group were decreased significantly,and lower than control group;NPY level increased significantly and higher than control group,with statistical significance(P<0.05). After treatment,complete com-pliance of observation group (71.43%) was obviously higher than that of control group (49.21%),with statistical significance (P<0.05). The maximum effect of observation group was significantly better than that of control group,with statistical signifi-cance(P<0.05). CONCLUSIONS:Citalopram in the treatment of post-stroke depression can significantly improve the patients' de-pression,nervous function and rehabilitation compliance of patient,showing significant therapeutic efficacy.