Logistic Regression Analysis of Risk Factors of Antituberculosis Drug-induced Liver Injury / 中国药房

ABSTRACT

OBJECTIVE:To explore the risk factors of antituberculosis drug-induced liver injury,and provide scientific basis for the prevention and treatment of drug-induced liver injury. METHODS:Retrospective analysis was adopted to investigate 410 pa-tients with antituberculosis treatment,single factor and multi-factor Logistic regression analysis were adopted to analyze the risk fac-tor that may induce liver injury in antituberculosis treatment. RESULTS:Single factor regression analysis showed that gender,hepa-titis history and drinking history were associated with drug-induced liver injury,multi-factor regression analysis showed that female (OR=2.320,P=0.021),hepatitis history(OR=4.332,P=0.006),drinking history(OR=4.512,P=0.003) and malnutrition(OR=3.202,P=0.015) were risk factors of antituberculosis drug-induced liver injury,and the degree of danger was drinking history>hepatitis history>malnutrition>female. CONCLUSIONS:The antituberculosis drug-induced liver injury is mainly affected by fe-male,hepatitis history,drinking history and malnutrition,the prevention of drug-induced liver injury based on related risk factors is helpful to improve the clinical symptoms and reduce the incidence of adverse reactions.