Effects of Room Temperature and Low Temperature Storage on the Chronergy of Domestic Cisatracurium / 中国药房

ABSTRACT

OBJECTIVE:To observe the effect of room temperature and low temperature storage on the chronergy of domes-tic cisatracurium. METHODS:90 patients undergoing elective surgery under general anesthesia were randomly divided into low tem-perature group,room temperature A group and room temperature B group,with 30 cases in each groups. Through single supramaxi-mal electrical stimulation of the adductor pollicis muscle,TOF-Watch SX muscle relaxation monitor was used to observe the degree of muscle relaxation. After induction of anesthesia and lost consciousness,the patients was given intravenous injection of cisatracu-rium 0.2 mg/kg;when muscle twitch decreased to the maximum inhibition degree,the patient received endotracheal intubation. The cisatracurium of low temperature group was stored in refrigerator at 2 to 5℃;that of room temperature A group and room tempera-ture B group was stored in incubator for 15 days or 30 days. The onset time,maximum inhibition degree of muscle twitch,clini-cal duration,recovery index and total chronergy were recorded in 3 groups. RESULTS:The maximal inhibition degree of muscle twitch reached 0 under the action of cisatracurium. There was no statistical significance in onset time and clinical duration between room temperature A group,room temperature B group and low temperature group(P>0.05);the recovery index and total chroner-gy of room temperature A group and room temperature B group were or longer than low temperature group,with statistical signifi-cance(P<0.05). CONCLUSIONS:Domestic cisatracurium stored at low temperature shows weaker effect on muscle relaxation.