Meta-analysis of the Efficacy and Safety of Astragali Radix Injection Combined with Trimetazidine in the Treatment of Viral Myocarditis / 中国药房

ABSTRACT

OBJECTIVE:To systematically evaluate the efficacy and safety of Astragali radix injection combined with trimetazi-dine in the treatment of viral myocarditis (VMC),and provide evidence-based reference for clinical treatment. METHODS:Re-trieved from PubMed,CBM,CJFD,VIP and Wanfang Database,randomized controlled trials(RCT) about Astragali radix injec-tion combined with trimetazidine(test group)vs. western conventional treatment and(or)trimetazidine alone(control group)in the treatment of VMC were collected. After quanlity evaluation and data extraction,Meta-analysis was conducted by using Rev Man 5.2 statistics software. RESULTS:A total of 14 RCT were included,involving 1 324 patients. Results of Meta-analysis showed the total effective rate[RR=1.32,95%CI(1.25,1.39),P<0.001],lactate dehydrogenase level [MD=-99.80,95%CI(-135.52,-64.08), P<0.001] and creatine kinase level [MD=-49.66,95%CI(-80.43,-18.90),P=0.002] in test group were significantly lower than those of control group,there was sgnificant difference between 2 groups;and there was no significant difference in the inci-dence of adverse reactions[RR=0.86,95%CI(0.48,1.55),P=0.61]. CONCLUSIONS:Astragali radix injection combined with trimetazidine has good efficacy and safety in the treatment of VMC.