Preparation of Dexibuprofen Sustained-release Pellets and Analysis on Drug Release Behavior / 中国药房
China Pharmacy
;
(12): 95-97, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-501372
ABSTRACT
OBJECTIVE:
To prepare dexibuprofen sustained-release pellets,and to analyze the drug release behavior in vitro.METHODS:
Centrifugal granulation powder layering-eudragit dispersion coating method was used to prepare dexibuprofen sus-tained-release pellets using 3%HPMC as adhesive agent. The formula of the pellets was optimized by orthogonal test with weight ra-tio of sucrose to dexibuprofen,weight ratio of HPMC to Eudragit NE30D and coating weight as factors,using 1,4 and 10 h accu-mulated release rate (Q) as index. The release of the drug from the pellets was analyzed.RESULTS:
The optimized formulation was that the proportion of sucrose to drug was 110,the weight ratio of HPMC to Eudragit NE30D was 1.51,the increased weight of coating material was 8%. Q1 h,Q4 h and Q10 h of prepared pellets were 21%,57% and 89%,respectively(n=3). The co-rrelation coefficient of zero-order,one-order and Higuchi equation release model were 0.956 6,0.989 9,0.996 5.CONCLUSIONS:
Prepared pellets show good sustained-release effect in vitro. Drug release of pellets is more in accordance with Higuchi equation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
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