Preparation and Characterization of Eugenol-β-cyclodextrin Inclusion Complex / 中国药房
China Pharmacy
;
(12): 86-89, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-501375
ABSTRACT
OBJECTIVE:
To optimize the inclusion technology of Eugenol-β-cyclodextrin (β-CD) inclusion complex,and to identify and characterize it.METHODS:
With the molar ratio of eugenol to β-CD,inclusion temperature and inclusion time as fac-tors,using the yield of inclusion compounds as index,the inclusion technology was optimized by orthogonal test. The formation of inclusion compound was identified by the spectra change of FT-IR,XRD and 1H NMR. Its structure was characterized by 1H RO-ESY NMR.RESULTS:
The optimized inclusion conditions were that the molar ratio of eugenol to β-CD was 1.01;inclusion tem-perature was 60 ℃;inclusion time was 2.0 h. And the yield of inclusion compound was 73.86%(RSD=0.17%,n=3). 1H NMR results ofβ-CD and its inclusion complex indicated that the optimum qualitative ratio of the inclusion complex was 1.01. The inter-molecular interaction between eugenol and β-CD was confirmed by the spectrum analysis of FT-IR and XRD. 1H ROESY NMR re-sults indicated the structure of inclusion complex mainly was that the phenyl of eugenol was in the cavity of β-CD,the vinyl was outside.CONCLUSIONS:
The inclusion technology is reasonable and feasible,and can be used for the inclusion of eugenol andβ-CD. The formation of inclusion compound is confirmed by the spectrum analysis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
/
Qualitative research
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
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