Effects of Common Percutaneous Enhancers on Transdermal Permeability of Cetirizine Hydrochloride / 中国药房
China Pharmacy
;
(12): 41-43, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-501386
ABSTRACT
OBJECTIVE:
To study the effects of common percutaneous enhancers on transdermal permeability of cetirizine hy-drochloride(CET).METHODS:
Using pH 7.4 phosphate buffer as receiving solution,accumulative permeation rate as index,mod-ified Franz diffusion cell was used to investigate the effects of common percutaneous enhancers on transdermal permeability of CET in skin of abdomen isolated from mice,such as azone (0.06%-2.5%),oleic acid (0.5%-10%),1,3-propanediol (0.5%-10%),propanetriol(0.5%-5%).RESULTS:
1,3- propanediol had no improvement effect on the permeability of CET. 24 h accu-mulative permeation amount of CET in 0.06% azone,0.5% oleic acid and 1% propanetriol were the highest among same types, being 227.94,85.25 and 215.15 μg/cm2,respectively.CONCLUSIONS:
Of four percutaneous enhancers,the transdermal enhanc-ing efficiencies from high to low are azone>glycerol>oleic acid>1,3-propanediol. Azone and glycerol have the conspicuous pene-tration enhancing effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
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