Effect of Intralesional Interleukin-2 on Murine Bladder Tumor / 대한비뇨기과학회지
Korean Journal of Urology
; : 1327-1332, 1996.
Article
in Ko
| WPRIM
| ID: wpr-50150
Responsible library:
WPRO
ABSTRACT
PURPOSE: We tried to evaluate the anticancer effect of intralesional interleukin-2 on murine bladder tumor. MATERIALS AND METHODS: In vitro direct anticancer effect of interleukin-2 upon MBT-2 cells was examined using MTT colorimetric assay in various concentration of human recombinant interleukin-2. Also in vivo study was carried out measuring the tumor implantation rates and growth of the implanted tumors on C3H/He mice receiving six consecutive injections of various concentrations of interleukin-2. RESULTS: No definite direct anticancer effect was found on in vitro study. Also, the tumor implantation rate and growth of the implanted tumors were similar whether interleukin-2's were injected or not. CONCLUSION: Intralesional injection of interleukin-2 does not seem to be effective upon murine bladder tumor.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Urinary Bladder
/
Urinary Bladder Neoplasms
/
Injections, Intralesional
/
Interleukin-2
Limits:
Animals
/
Humans
Language:
Ko
Journal:
Korean Journal of Urology
Year:
1996
Type:
Article