Comparative Study on Efficacy and Safety of Lobaplatin/Cisplatin Combined with Etoposide in the Treat-ment of Primary Small Cell Lung Cancer / 中国药房

ABSTRACT

OBJECTIVE:To compare the efficacy of lobaplatin/ cisplatin combined with etoposide in the treatment of primary small cell lung cancer. METHODS:60 patients with small cell lung cancer were randomly divided into observation group and con-trol group. Observation group was given 30 mg/m2 Lobaplatin injection,adding into 500 ml 5% Glucose injection,d1,by intrave-nous infusion for 1 h+100 mg/m2 Etoposide injection,adding into 500 ml 0.9%Sodium chloride injection,d1-3,by intravenous infu-sion for 1 h. Control group was given 25 mg/m2 Cisplatin injection,adding into 500 ml 0.9% Sodium chloride injection,d1-3,by in-travenous infusion for 1 h+Etoposide injection(the same dose with observation group). 3-week was regarded as a chemotherapy cy-cle. The clinical efficacy and toxicities in 2 groups were observed. RESULTS:There were more than 2 cycles for both groups. There was no significant difference in the total effective rate between 2 groups(P>0.05),and the incidences of nausea,vomiting and diarrhea in observation group were significantly lower than control group,the differences were statistically significant (P<0.05). CONCLUSIONS:Lobaplatin/ cisplatin combined with etoposide has similar efficacy in the treatment of primary small cell lung cancer,and lobaplatin has better safety.