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Research progress in benchmark dose in risk assessment of long-team exposure toxicity / 军事医学
Military Medical Sciences ; (12): 851-855, 2016.
Article in Chinese | WPRIM | ID: wpr-501543
ABSTRACT
The purpose of risk assessment is to evaluate the permissible exposure level under specific risk factors.To extrapolate the human acceptable daily intake (ADI) and/or reference dose (RfD), the traditional method uses the no-observed-adverse-effect level ( NOAEL ) to quantify toxicity after being divided by uncertainty factor.There are many limitations with NOAEL method in safety evaluation,for it relies too much on experimental design.Benchmark dose ( BMD) approach is a more reliable method with many advantages.BMD approach and its analysis software, the advantages of BMD over NOAEL, the application and methodological perfection in risk assessment of long-team exposure toxicity are presented in this review.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Risk factors Language: Chinese Journal: Military Medical Sciences Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Risk factors Language: Chinese Journal: Military Medical Sciences Year: 2016 Type: Article