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Neuroprotective effect of Nrf2/HO-1 signaling pathway in cerebral ischemia combined with diabetes mellitus / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases ; (12): 765-768, 2016.
Article in Chinese | WPRIM | ID: wpr-501738
ABSTRACT
Glucagon and its analogues are a intestinal stimulating insulin screened by the small intestinal L cells. It can smoothly penetrate the blood-brain barrier into the brain tissue and play a neuropro-tective role. Liraglutide and glucagon and its analogues have higher homology. After entering the brain tissue, it is able to bind with the related receptors and activates Nrf2/HO-1 signaling pathway and thus reducing the production of oxidative stress products, increases the glutathione, heme oxygen synthase, superoxide dismutase and other phase Ⅱ detoxification enzymes, promotes angiogenesis, and protects the nerve cells of diabetes combined with cerebral ischemia injury.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Cerebrovascular Diseases Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Cerebrovascular Diseases Year: 2016 Type: Article