Comparative observation of the effect of etomidate and propofol on circulatory system and the depth of anesthesia in laparoscopic surgery of ectopic pregnancy / 中国生化药物杂志

ABSTRACT

Objective To investigate the effects of etomidate and propofol on circulatory system and the depth of anesthesia in laparoscopic surgery of ectopic pregnancy.Methods From January 2014 to January 2015, 40 patients with ectopic pregnancy in our hospital were selected and divided into the etomidate group and propofol group according to the principle of complete random grouping.Patients in the etomidate group received etomidate induced anesthesia, and the patients in the propofol group received propofol induced anesthesia.Hemodynamic parameters and bispectral index(BIS) of two groups were evaluated at 4 time points.The incidence of postoperative nausea and vomiting, chills and bronchospasm were recored.Results There was no significant difference in heart rate (HR),systolic blood pressure (SBP) and diastolic blood pressure(DBP) between the two groups at T0,T2and T3.But at the time of induction(T1), the heart rate of patients in propofol group was significantly lower than that in etomidate group(P<0.05).While T1, compared with etomidate group, the HR and SBP significantly decreased and DBP increased in the propofol group (P<0.05), The HR and SBP at T1of patients in the propofol group and etomidate group decreased significantly and DBP increased when compared with T0(P<0.05).and etomidate group decreased significantly compared with T0 ( P <0.05 ).There were no significant differences in BIS indexes at four time points.However, BIS indexes at T1 ,T2 and T3 were significantly lower than T0 ( P <0.05 ).There was no significant difference in three kinds of complications rates in two groups.Conclusion Etomidate, compared with propofol, can better control the cardiovascular response during induction of anesthesia.Both drugs have a consistent depth of anesthesia.There is no difference in the incidence of complications.Etomidate is more suitable for patients with ectopic pregnancy laparoscopic surgery.