Relevant research progress of interstitial cells of Cajal / 中华实用儿科临床杂志

ABSTRACT

Cajal initially identified interstitial cells of Cajal (ICC).In recent decades the researches on ICC were rapid.It is known to all that ICC contribute to several important functions in the gastrointestinal tract includinggeneration of electrical slow wave activity,coordination of pacemaker activity and active propagation of slow waves,transduction of motor neural inputs from the enteric nervous system,and mechanosensation to stretch of gastrointestinal muscles.The changes of morphology,distribution,number,phenotypic in ICC might affect on the gastrointestinal function,and might lead to gastrointestinal disease.Expression of c-kit has an important role in the ICC.Regulation of SCF/c-kit signaling system can lead to changes in morphology of ICC.In the gastrointestinal tract,motilin receptor expression in the ICC.The promotion of motilin receptor agonist to intestinal tract were mediated by ICC.ICC can be isolated and subcultured.