Influence of chromatin structure on the radiation sensitivity of tumor cells / 中华放射医学与防护杂志

ABSTRACT

Cumulative evidence demonstrated that the chromatin modification plays important roles in the processes of DNA replication,transcription,repair and recombination.Both of the generation of DNA lesions and the activation of DNA damage response (DDR) to ionizing radiation could be affected by the chromatin modifications.This paper reviewed the recent research progresses in the chromatin structure modifications and its role in DDR,especially the influence of characteristic chromatin structure and histone modification on the radiation sensitivity of tumor cells.