Residual Determination of 7 Organic Solvents in PicrosideⅡRaw Material by Head-space GC / 中国药房
China Pharmacy
;
(12): 3859-3861, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-502391
ABSTRACT
OBJECTIVE:
To establish the method for the residual determination of 7 organic solvents in picrosideⅡraw materi-als.METHODS:
Head-space GC was performed on the capillary column of 6% cyanopropyl phenyl-94% dimethyl polysiloxane (DB-624) by temperature programming,the temperature of injector was 200 ℃,temperature of flame ionization detector was 250 ℃,the flow rate of N2 was 35 ml/min,and split ration was 10∶1,headspace sampling was adopted with the volume of 1 ml, the heating temperature of headspace sampling was 85 ℃,heating time was 45 min.RESULTS:
The good linear relationship of methanol,ethanol,ethylacetate,methylbenzene,benzene,phenylethylene and divinglbenzene had been obtained(r=0.999 6-0.999 9);RSDs of precision stability test were less than 3%;average recoveries was in the range of 78.0%-104.9%(RSDs were 0.65%-2.47%,n=6)respectively.CONCLUSIONS:
The method is specific,rapid,simple and accurate,and can be used for the determination of residual organic solvents in picrosideⅡraw materials.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2015
Type:
Article
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