Research on Synthesis Technology of Ligustilide Dipolymer / 中国药房
China Pharmacy
;
(12): 3923-3925, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-502680
ABSTRACT
OBJECTIVE:
To study the synthesis technology of Ligustilide dipolymer (compound Ⅰ).METHODS:
Using phthalic anhydride(compoundⅡ)as raw materials,sodium borohydride was reduced to phthalide(compound Ⅲ),and then syn-thesize ligustilide dipolymer after 4 steps. Ligustilide dipolymer was characterized by 1H-NMR and 13C-NMR. The synthesis technol-ogy of fifth step was optimized by orthogonal test with catalyzer,reaction temperature and reaction time as factors using yield as in-dex. The validation test was conducted.RESULTS:
The optimal synthesis technology of fifth step was as follows as aluminium mu-riate of catalyzer,reaction temperature of 150 ℃,reaction time of 5 h. The average yield of validation test was 56.16%(RSD=1.23%,n=3). Total reaction yield was 24.4%,and the purity of target product was 99.4%.CONCLUSIONS:
Ligustilide dipoly-mer is synthesized successfully;synthetic process is stable,and its quality is controllable.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2015
Type:
Article
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