Role of Maternal PAPPA and PIGF Levels at Second Trimester in the Prediction of Preeclampsia / 现代检验医学杂志

ABSTRACT

Objective To determine the PAPPA and PIGF levels in maternal serum at second trimester(15 to19 weeks)to e-valuate the role of these in the prediction of preeclampsia at last trimester.Methods Using premeasure postmeasure design, identified 204 singleton pregnancies within 15 to 19 weeks of gestation that followed 89 who had developed preeclampsia during 36 and 40 weeks,gestation at Weinan Municipal Maternal and Child Health Hospital at June 2013 and July 2015,115 with normotensive pregnant.PAPPA and PIGF concentration were determined.Results ①PAPPA and PIGF levels were significantly reduced in the preeclampsia groups compared to the normotensive pregnant group at second trimester (2.3μg/ml vs 4.6μg/ml,U=11.31,P=0.017;78 pg/ml vs 160 pg/ml,U=8.26,P=0.003).②PAPPA and PIGF levels were sig-nificantly reduced at last trimester compared to second trimester in the preeclampsia groups (1.6μg/ml vs 2.3μg/ml,U=9.41,P=0.011;56 pg/ml vs 78 pg/ml,U=6.77,P=0.023).③Receiver operating characteristic curve analysis showed that at second trimester(at 15 to 19 weeks)a cutoff value of 2.2μg/ml for PAPPA and a cutoff value of 75pg/ml for PIGF were able to predict preeclampsia with specificity,sensitivity and area under the curve (AUC)61.7%,87.8%,AUC 0.86(95%CI,0.83~0.91)respectively.Conclusion Measuring PAPPA and PIGF in the second trimester(at 15 to 19 weeks)may be useful in the prediction of preeclampsia.