Analysis of the Correlation between Ornidazole Salivary Concentration and Plasma Concentration / 中国药房
China Pharmacy
;
(12): 4074-4077, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-502993
ABSTRACT
OBJECTIVE:
To explore the correlation between ornidazole (ONZ) salivary concentration and plasma concentra-tions in healthy subjects,and to provide reference for clinical therapeutic drug monitoring.METHODS:
24 healthy volunteers were selected. After oral administration of ONZ capsules 1.00 g,their venous blood and saliva were collected at 0.25,0.5,1.5,5.5, 10.5,24.5 and 43.5 h after medication. HPLC method was used to determine the plasma and salivary concentrations of ONZ. The correlation between the two was analyzed.RESULTS:
The peak values of plasma and salivary ONZ concentrations appeared imme-diately at 1.5 h after administration and the peak values were(0.96±0.15)μg/ml and(0.93±0.15)μg/ml;salivary concentration of ONZ was lower than plasma concentration at each time points,but there was no statistical significance (P>0.05);the regres-sion equation of salivary ONZ concentration and plasma concentration was csaliva=1.176 5cplasma-0.199 4(r=0.990 1). The ratio of salivary concentration and plasma concentration of ONZ (S/P) was (0.91 ± 0.06),showing positive correlation (r=0.632-0.970, P<0.05).CONCLUSIONS:
The salivary ONZ concentration is significantly correlated with plasma concentration in healthy peo-ple,so saliva can be used for therapeutic drug monitoring.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
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