Study on the correlation between serum Irisin and type 2 diabetic nephropathy / 重庆医学

ABSTRACT

Objective To explore the association of serum Irisin with diabetic nephropathy(DN) in patients with type 2 dia‐betes mellitus(T2DM) .Methods Totally 40 cases of patients with newly diagnosed T2DM(SDM group) ,41 cases of patients with early diabetic nephropathy(EDN group) ,and 42 cases of patients with clinical diabetic nephropathy(CDN group) were selected ,an‐other 40 healthy individuals with normal glucose tolerance were selected as the controls(NC group) .Serum Irisin was measured by using ELISA method .Results (1) The serum Irisin levels of four groups from high to low wereNC group(320 .48 ± 107 .03)ng/mL ,SDM group(291 .53 ± 101 .01)ng/mL ,EDN group(278 .54 ± 93 .48)ng/mL ,CDN group(209 .12 ± 88 .53)ng/mL ,and the difference was statistically significant(P<0 .05) .(2)The correlation analysis showed that Irisin level was negatively correlated with insulin resistance index (HOMA‐IR) ,fasting insulin (FINS) ,FPG ,HbA1c ,Scr ,BUN ,TNF‐αand UAlb/Cr(r= -0 .592 ,-0 .610 ,-0 .614 ,-0 .638 ,-0 .538 ,-0 .552 ,-0 .589 ,-0 .561 ,P<0 .05) ,and positively correlated with superoxide dismutase (SOD) and HDL(r=0 .578 ,0 .556 ,P<0 .05) .(3)The regression analysis showed that UAlb/Cr and HOMA‐IR were the independent influen‐cing factors of Irisin .Conclusion The level of serum Irisin in DN patients is decreased ,and the level of Irisin may be correlated with the severity of DN .