The Trend of Eradication Rates of First-line Triple Therapy for Helicobacter pylori Infection: Single Center Experience for Recent Eight Years / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 156-161, 2006.
Article
in Korean
| WPRIM
| ID: wpr-50303
ABSTRACT
BACKGROUND/AIMS:
The prevalence of antibiotic resistance in Helicobacter pylori (H. pylori) infection has been reported to be increasing. However, the recent trend of eradication rates of H. pylori using first-line triple regimens has been rarely issued. Therefore, we aimed to determine the trend of H. pylori eradication rates in single center for recent eight years.METHODS:
From January 1998 through October 2005, H. pylori eradication rates in 525 patients with H. pylori-positive peptic ulcer disease who received one-week triple regimens were retrospectively evaluated according to years, regimens, and ulcer locations.RESULTS:
The overall H. pylori eradication rate was 78.7%. Yearly eradication rates from the year 1998 to 2005 were 83.7%, 80.4%, 81.4%, 78.8%, 75.3%, 77.6%, 78.9% and 77.6% consecutively by per-protocol analysis, However, no definite evidence of decreasing tendency of eradication rate was seen during the past eight years (p=0.419). Furthermore, there was no significant difference in the eradication rates according to the ulcer locations and regimens.CONCLUSIONS:
Although it is found that there is no definite statistical evidence of decreasing trend for H. pylori eradication rate during past eight years, those for recent 5 years were lower than 80%, which suggests that we should scrutinize the trend of first-line H. pylori eradication rate, and concern for the expected lower rates in the near future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retrospective Studies
/
Helicobacter pylori
/
Helicobacter Infections
/
Treatment Outcome
/
Clarithromycin
/
Drug Therapy, Combination
/
Amoxicillin
/
Metronidazole
/
Anti-Bacterial Agents
Type of study:
Observational study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2006
Type:
Article
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