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Study on the Stability of Guhong Injection in Infusions Commonly Used in Clinics / 中国药师
China Pharmacist ; (12): 1999-2004, 2016.
Article in Chinese | WPRIM | ID: wpr-503304
ABSTRACT

Objective:

To investigate the stability of Guhong injection in infusions commonly used in clinics.

Methods:

The chan-ges in pH value, appearance and insoluble particles were observed, and the contents of aceglutamide, uridine, adenosine, guanosine, lilac glycosides, hydroxyl safflower yellow prime A and anhydrosafflor yellow B in Guhong injection were determined by HPLC-DAD in 8 h after the compatibility respectively at 5, 25 and 35℃ under the condition of avoiding light, indoor illumination and ultraviolet irra-diation, respectively. The contents of the related substances of acetyl glutamine were detected by HPLC.

Results:

In 8 h, the appear-ance, pH and insoluble particles of all compatibility solution had no significant changes. The content of aceglutamide in compatibility solution was decreased under the condition of ultraviolet irradiation (35 ℃), and the content of compositions in the other compatibility solution showed no significant changes. Under the condition of avoiding light and indoor illumination, the content of relative substances showed no significant changes before and after the compatibility, and met the relevant provisions. But under ultraviolet light, with tem-perature increasing and time prolonging, the content of the related substances was increased significantly.

Conclusion:

Guhong injec-tion is stable in 5 % glucose injection, 10 % glucose injection and sodium chloride injection in 4 hours, while the mixtures should a-void sunlight during the use.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2016 Type: Article