Recent advances in surface markers of gastric cancer stem cells / 中国组织工程研究

ABSTRACT

BACKGROUND:It has been observed recently that tumor recurrence is closely related to cancer stem cel s. Cancer stem cel theory provides a new avenue for the study of gastric cancer pathogenesis, diagnosis and treatment. To determine the cel phenotype is helpful to target gastric cancer stem cel s, and contributes to exploring the self-renewal and differentiation of gastric cancer stem cel s, further providing new ideas for the treatment of gastric cancer. However, the phenotype of gastric cancer stem cel s remains controversial. OBJECTIVE:To review the research progress in gastric cancer stem cel phenotype. METHODS:A computer-based online search of PubMed database was performed to search related articles published between January 1965 and October 2015 with the key words of“Gastric Cancer Stem Cel s”in English. Sixty-eight articles were included for final analysis. RESULTS AND CONCLUSION:Traditional cancer stem cel phenotypes are unsuitable for marking gastric cancer stem cel s. Studies have found that CD90 expresses in primary gastric cancers, and cancer stem cel spheres would be required via serum-free culture by CD90 maker. CD24 expression can improve the adhesion, invasion and migration of gastric cancer cel s. Further studies have confirmed that a lot of cel s positive for both CD44 and CD54 can be found in patients with early recurrence of gastric cancer rather than those with advanced recurrence, and CD44 and CD54 expression in tumor cel s is likely to be an important cause of gastric cancer occurrence and recurrence. By analyzing the sorting, CD44+CD24+CD90+CD54+is likely to be the gastric cancer stem cel phenotype.