Three-dimensional temperature distribution during femur tumor hyperthermia based on three-dimensional temperature field / 中国组织工程研究

ABSTRACT

BACKGROUND:Temperature measure methods of human tissue include destructive measurement and nondestructive measurement. Destructive measurement cannot measure three-dimensional (3D) temperature field and nondestructive measure is stil in the research stage. It is better way to build a mathematical and physical model to predict and simulate femur tumor hyperthermia. OBJECTIVE:To obtain the three-dimensional temperature distribution of femur and its surrounding tissues during tumor hyperthermia. METHODS:3D temperature distribution was obtained by using finite element method on the basis of heat conduction theory, Laplace equation, Pennes bio-heat transfer equation, thermo physical parameters of bone tissues, the boundary condition, and initial conditions. RESULTS AND CONCLUSION:The femur had good hinder effect to heat transfer. Femoral temperature curve in the 3D space showed el ipsoid distribution with heat source as the center;the closer from heat source, the greater the temperature gradient was. The three major diameters of temperature isoline were different at 50℃, which is maximum in cross section and minimum in the sagittal plane. In the three directions of the femur, transfer capability of temperature was different, so the radius of the inactivation of the tumor was also different. Because the 3D temperature space distribution of femur is asymmetry during hyperthermia, the necessary method is to use more than a heat source in order to avoid residual cancer tissue or destructive normal tissue.