The preventive effect of rivaroxaban combine with intermittent pneumatic compression in patients after hip replacement / 中国生化药物杂志

ABSTRACT

Objective To explore the preventive effect of rivaroxaban combined with intermittent pneumatic compression in patients after hip replacement.Methods 84 cases with hip arthroplasty were randomly divided into control group and experiment group.The control group of 42 cases(47 hips)were given low molecular weight heparin combined with intermittent pneumatic compression.The experiment group of 42 cases(48 hips)were given rivaroxaban combined with intermittent pneumatic compression.Coagulation indicator and hemorheology were compared before treatment,1 weeks after treatment and 2 weeks after treatment,and patients were detected by lower extremity ultrasound detection,prevention of thrombosis and bleeding recorded during treatment status.Results APTT and TT of the experiment group were lower than the control group after 2 weeks of treatment with statistical significance(P<0.05);The deep venous thrombosis of experiment group was 2 cases(4.76%)and the control group was 6 cases(14.29%),with no statistical significance.Two groups of patients with perioperative bleeding after drainage was not statistically significant.Conclusion Compared with low molecular heparin,rivaroxaban combine with intermittent pneumatic compression has a lower extremity deep venous thrombosis prevention after hip replacement surgery,without increasing the risk of bleeding.