Association between XPC rs2228000 (C/T)polymorphism and the susceptibility of breast cancer:a Meta-analysis / 国际肿瘤学杂志

ABSTRACT

Objective To quantitatively examine the relationship between xeroderma pigmentosum complementation C group (XPC)rs2228000 (C /T)polymorphism and the susceptibility of breast cancer. Methods The relevant case-control studies published up to December 2015 which investigated XPC rs2228000 (C /T)polymorphism and breast cancer risk were identified by searching PubMed,Cochrane Library,Chinese Biomedical Literature Data,Wanfang Database,China National Knowledge Infrastructure and VIP Database. Meta-analysis was conducted using STATA 12.0 software and odds ratio (OR)with its 95%CI were estimated. Results A total of 8 researches involving 9 case-control studies (3 850 breast cancer cases and 5 047 healthy controls) were included.The Meta-analysis showed that there was statistical association between XPC rs2228000(C /T)variance and breast cancer risk in the homozygous model (TT vs.CCOR =1.28,95%CI1.08-1.52,Z =2.80,P =0.005)and recessive model (TT vs.TC +CCOR =1.23,95%CI1.05-1.43, Z =2.64,P =0.008),but not in the allele model,heterozygote model and dominant model.In the subgroup of ethnicity and genotyping methods,the different significant correlation was existed between them under Asian and PCR-RFLP in genetic models (T vs.COR =1.21,95%CI1.05-1.40,Z =2.63,P =0.009;TT vs. CCOR =1.55,95%CI1.13-2.13,Z =2.70,P =0.007;TT +TC vs.CCOR =1.26,95%CI1.02-1.55,Z =2.19,P =0.028;TT vs.TC +CCOR =1.39,95%CI1.04-1.87,Z =2.23,P =0.026).We also found significant association between them in subgroup of population-based controls in the homozygous model (TT vs.CCOR =1.27,95%CI1.02-1.57,Z =2.16,P =0.031).Conclusion XPC rs2228000 (C /T)polymorphism may be associated with the susceptibility of breast cancer,especially in Asian,and gene-type TT may increase the risk of breast cancer.